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This effect likely relates to the peptide's GABAergic and anti-NMDA activities
NEJM, 2022 6
Many patients take their GLP-1 medication on one day and manage their insulin separately
Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms
Novo Nordisk reined in its growth forecasts for the year in its second-quarter financial results update, blaming "persistent use of compounded GLP-1s, slower-than-expected market expansion, and competition." Compounding of semaglutide should have come to a halt in the US since the drug was removed from the FDA list of medicines in short supply, but various companies continue to provide compounded GLP-1s under a loophole that allows the sale of 'personalised' formulations
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